White matter microstructure associated with anhedonia among individuals with bipolar disorders and high-risk for bipolar disorders.

ABSTRACT:

Background

Anhedonia - a key symptom of depression - is highly associated with poorer outcomes and suicidal behavior. Alterations in the circuitry of reward-related brain regions have been robustly associated with anhedonia in unipolar depression, but not bipolar disorder (BD). We investigated white matter microstructures associated with anhedonia in participants with BD types I and II and first-degree relatives of patients with BD (BD-siblings).

Methods

Eighty participants (BD types I and II: 56 [70%], and BD-siblings: 24 [30%]) underwent diffusion tensor imaging (DTI); Fractional anisotropy (FA) of different tracts were computed. Anhedonia was assessed using item 8, ("inability to feel'') of the MADRS scale. General linear models were used to compare the FA of different tr

SUBMITTER: Diaz AP 

PROVIDER: S-EPMC8828704 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature