Metabolic abnormalities in the basal ganglia and cerebellum in bipolar disorder: A multi-modal MR study.

ABSTRACT:

Aims

Bipolar type I disorder (BD) is characterized by severe mood swings and occurs in about 1% of the population. The mechanisms underlying the disorder remain unknown. Prior studies have suggested abnormalities in brain metabolism using ¹H and ³¹P magnetic resonance spectroscopy (MRS). Supporting altered metabolism, in previous studies we found T1ρ relaxation times in the cerebellum were elevated in participants with BD. In addition, T1ρ relaxation times in the basal ganglia were lower in participants with BD experiencing depressed mood. Based on these findings, this study sought to probe brain metabolism with a focus of extending these assessments to the cerebellum.

Methods

This study collected data from 64 participants with Bipolar type I disorder (

SUBMITTER: Magnotta VA 

PROVIDER: S-EPMC8828710 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature