Compromised reactive but intact proactive inhibitory motor control in Tourette disorder.

ABSTRACT: Tourette disorder (TD) is characterized by tics, which are sudden repetitive involuntary movements or vocalizations. Deficits in inhibitory control in TD patients remain inconclusive from the traditional method of estimating the ability to stop an impending action, which requires careful interpretation of a metric derived from race model. One possible explanation for these inconsistencies is that race model's assumptions of independent and stochastic rise of GO and STOP process to a fixed threshold are often violated, making the classical metric to assess inhibitory control less robust. Here, we used a pair of metrics derived from a recent alternative model to address why stopping performance in TD is unaffected despite atypical neural circuitry. These new metrics distinguish between proac

SUBMITTER: Indrajeet I 

PROVIDER: S-EPMC8828748 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature