Ultrasound does not activate but can inhibit in vivo mammalian nerves across a wide range of parameters.

ABSTRACT: Ultrasound (US) has been shown to stimulate brain circuits, however, the ability to excite peripheral nerves with US remains controversial. To the best of our knowledge, there is still no in vivo neural recording study that has applied US stimulation to a nerve isolated from surrounding tissue to confirm direct activation effects. Here, we show that US cannot excite an isolated mammalian sciatic nerve in an in vivo preparation, even at high pressures (relative to levels recommended in the FDA guidance for diagnostic ultrasound) and for a wide range of parameters, including different pulse patterns and center frequencies. US can, however, reliably inhibit nerve activity whereby greater suppression is correlated with increases in nerve temperature. By prohibiting the nerve temperature from i

SUBMITTER: Guo H 

PROVIDER: S-EPMC8828880 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature