Characterization of Kinesin Family Member 2C as a Proto-Oncogene in Cervical Cancer.

ABSTRACT: Kinesin family member 2C (KIF2C) is known as an oncogenic gene to regulate tumor progression and metastasis. However, its pan-cancer analysis has not been reported. In this study, we comprehensively analyzed the characteristics of KIF2C in various cancers. We found that KIF2C was highly expressed and corresponded to a poor prognosis in various cancers. We also found a significant correlation between KIF2C and clinicopathological characteristics, particularly in cervical cancer, which is the most common gynecological malignancy and is the second leading cause of cancer-related deaths among women worldwide. KIF2C mutation is strongly associated with the survival rate of cervical cancer, and KIF2C expression was significantly upregulated in cervical cancer t

SUBMITTER: Yang J 

PROVIDER: S-EPMC8828917 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature