Characterization of Pipefish Immune Cell Populations Through Single-Cell Transcriptomics.

ABSTRACT: Teleost adaptive immune systems have evolved with more flexibility than previously assumed. A particularly enigmatic system to address immune system modifications in the evolutionary past is represented by the Syngnathids, the family of pipefishes, seahorses and seadragons. These small fishes with their unique male pregnancy have lost the spleen as an important immune organ as well as a functional major histocompatibility class II (MHC II) pathway. How these evolutionary changes have impacted immune cell population dynamics have up to this point remained unexplored. Here, we present the first immune cell repertoire characterization of a syngnathid fish (Syngnathus typhle) using single-cell transcriptomics. Gene expression profiles of individual cells extracted from blood and head-ki

SUBMITTER: Parker J 

PROVIDER: S-EPMC8828949 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature