Thicker macula in asymptomatic APOE Ɛ4 middle-aged adults at high AD risk.

ABSTRACT:

Introduction

We compared retinal layers' thickness between apolipoprotein E (APOE) Ɛ4 carriers and non-carriers in a cohort of cognitively normal middle-aged adults enriched for Alzheimer's disease (AD) risk.

Methods

Participants (N = 245) underwent spectral domain optical coherence tomography. Multivariate analyses of covariance adjusting for age, sex, education, and best corrected vision acuity was used to compare retinal thickness between APOE groups.

Results

Participants' mean age was 59.60 (standard deviation = 6.42) with 66.4% women and 32.2% APOE Ɛ4 carriers. Greater macular full thickness was observed in APOE Ɛ4 carriers compared to non-carriers (P = .017), reaching statistical significance for the inner and outer nasal (P

SUBMITTER: Rotenstreich Y 

PROVIDER: S-EPMC8828987 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature