Crosswalk study on blood collection-tube types for Alzheimer's disease biomarkers.

ABSTRACT:

Introduction

Blood-based Alzheimer's disease (AD) biomarkers show promise, but pre-analytical protocol differences may pose problems. We examined seven AD blood biomarkers (amyloid beta [ Aβ]42 , Aβ40 , phosphorylatedtau[p-tau181 , total tau [t-tau], neurofilament light chain [NfL], Aβ4240, and p-tau181Aβ42 ) in three collection tube types (ethylenediaminetetraacetic acid [EDTA] plasma, heparin plasma, serum).

Methods

Plasma and serum were obtained from cerebrospinal fluid or amyloid positron emission tomography-positive and -negative participants (N = 38) in the Wisconsin Registry for Alzheimer's Prevention. We modeled AD biomarker values observed in EDTA plasma versus heparin plasma and serum, and assessed correspondence with brain amyloidosis.

Results

Results sugge

SUBMITTER: Jonaitis EM 

PROVIDER: S-EPMC8828996 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature