Longitudinal Assessment of Prenatal, Perinatal, and Early-Life Aflatoxin B₁ Exposure in 828 Mother-Child Dyads from Bangladesh and Malawi.

ABSTRACT:

Background

In utero or early-life exposure to aflatoxin, which contaminates staple crops in disadvantaged settings, may compromise pregnancy and infant outcomes, but investigations into the extent, persistence, and determinants of aflatoxin exposure at these life stages have lacked longitudinal data collection and broad geographic representation.

Objectives

Aflatoxin exposure and selected determinants thereof were characterized in mother-child dyads with serial plasma/serum samples in prenatal, perinatal, and early life in Malawi and Bangladesh.

Methods

Circulating aflatoxin B₁ (AFB₁)-lysine albumin adducts were measured in dyads from Bangladesh (n = 573; maternal first and third trimester, 3 mo postpartum, cord blood, infant 24 mo) and Ma

SUBMITTER: Smith JW 

PROVIDER: S-EPMC8829025 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature