Global colistin use: a review of the emergence of resistant Enterobacterales and the impact on their genetic basis.

ABSTRACT: The dramatic global rise of MDR and XDR Enterobacterales in human medicine forced clinicians to the reintroduction of colistin as last-resort drug. Meanwhile, colistin is used in the veterinary medicine since its discovery, leading to a steadily increasing prevalence of resistant isolates in the livestock and meat-based food sector. Consequently, transmission of resistant isolates from animals to humans, acquisition via food and exposure to colistin in the clinic are reasons for the increased prevalence of colistin-resistant Enterobacterales in humans in the last decades. Initially, resistance mechanisms were caused by mutations in chromosomal genes. However, since the discovery in 2015, the focus has shifted exclusively to mobile colistin resistances (mcr). This review will advance the un

SUBMITTER: Binsker U 

PROVIDER: S-EPMC8829026 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature