Over-Expression and Prognostic Significance of FATP5, as a New Biomarker, in Colorectal Carcinoma.

ABSTRACT: Background: Fatty acid transporters (FATPs) family play an important role in the uptake and metabolism regulation of long-chain fatty acids, which influence the occurrence and developing of multiple tumors. Fatty acid transporter 5(FATP5), a member of FATPs family, participates in fatty acid transport and lipid metabolism and is related to tumor development, whose mechanism in colorectal cancer (CRC) remains unclear. Methods: In this study, we comprehensively utilized a range of relevant bioinformatic tools along with multiple databases to analyze the expression of FATPs family and investigate the biological function and prognostic value of FATP5 in CRC. Besides, cell proliferation and cell cycle distribution analysis, western blotting and immunohistochemistry (IHC) further v

SUBMITTER: Geng QS 

PROVIDER: S-EPMC8829069 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature