Adrenergic control of the cardiovascular system in deer mice native to high altitude.

ABSTRACT: Studies of animals native to high altitude can provide valuable insight into physiological mechanisms and evolution of performance in challenging environments. We investigated how mechanisms controlling cardiovascular function may have evolved in deer mice (Peromyscus maniculatus) native to high altitude. High-altitude deer mice and low-altitude white-footed mice (P. leucopus) were bred in captivity at sea level, and first-generation lab progeny were raised to adulthood and acclimated to normoxia or hypoxia. We then used pharmacological agents to examine the capacity for adrenergic receptor stimulation to modulate heart rate (f _H) and mean arterial pressure (P _mean) in anaesthetized mice, and used cardiac pressure-volume catheters to evalua

SUBMITTER: Wearing OH 

PROVIDER: S-EPMC8829085 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature