Prognostic Value and Therapeutic Potential of CBX Family Members in Ovarian Cancer.

ABSTRACT: Background: Ovarian cancer (OV) is one of the common malignant tumors and has a poor prognosis. Chromobox (CBX) family proteins are critical components of epigenetic regulation complexes that repress target genes transcriptionally via chromatin modification. Some studies have investigated the function specifications among several CBXs members in multiple cancer types, however, little is known about the functions and prognostic roles of distinct CBXs family proteins in ovarian cancer. Methods: In this study, several bioinformatics databases and in vitro experiments were used to analyze the expression profiles, prognostic values, and therapeutic potential of the CBXs family (CBX1-8) in ovarian cancer. Results: It was found that higher expression of CBX3/8 a

SUBMITTER: Hu K 

PROVIDER: S-EPMC8829121 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature