Human Immune System Diseasome Networks and Female Oviductal Microenvironment: New Horizons to be Discovered.

ABSTRACT: Human hypofertility and infertility are two worldwide conditions experiencing nowadays an alarming increase due to a complex ensemble of events. The immune system has been suggested as one of the responsible for some of the etiopathogenic mechanisms involved in these conditions. To shed some light into the strong correlation between the reproductive and immune system, as can be inferred by the several and valuable manuscripts published to date, here we built a network using a useful bioinformatic tool (DisGeNET), in which the key genes involved in the sperm-oviduct interaction were linked. This constitutes an important event related with Human fertility since this interaction, and specially the spermatozoa, represents a not-self entity immunotolerated by the female. As a result, we discove

SUBMITTER: Taraschi A 

PROVIDER: S-EPMC8829125 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature