In silico molecular docking and in vitro analysis of ethanolic extract Ocimum sanctum Linn.: Inhibitory and apoptotic effects against non-small cell lung cancer.

ABSTRACT:

Background and aim

Lung cancer, especially non-small cell lung cancer (NSCLC), has been identified as the leading cause of cancer deaths worldwide. The mortality rate from lung cancer has been estimated to be 18.4%. Until now, conventional treatments have not yielded optimal results, thus necessitating an investigation into the use of traditional herbal plants as potential candidates for its treatment. This study aimed to determine the inhibitory and apoptotic activity of the ethanolic extract from Ocimum sanctum Linn. (EEOS) by in silico molecular docking and through in vitro studies using NSCLC cells (A549 cell line).

Materials and methods

Dried simplicia of Ocimum sanctum was converted into EEOS using the maceration method. Spectrophotometry wa

SUBMITTER: Kustiati U 

PROVIDER: S-EPMC8829409 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature