Biomaterials via peptide assembly: Design, characterization, and application in tissue engineering.

ABSTRACT: A core challenge in biomaterials, with both fundamental significance and technological relevance, concerns the rational design of bioactive microenvironments. Designed properly, peptides can undergo supramolecular assembly into dynamic, physical hydrogels that mimic the mechanical, topological, and biochemical features of native tissue microenvironments. The relatively facile, inexpensive, and automatable preparation of peptides, coupled with low batch-to-batch variability, motivates the expanded use of assembling peptide hydrogels for biomedical applications. Integral to realizing dynamic peptide assemblies as functional biomaterials for tissue engineering is an understanding of the molecular and macroscopic features that govern assembly, morphology, and biological interactions. In this r

SUBMITTER: Gray VP 

PROVIDER: S-EPMC8829437 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature