Low Exposure to Direct Oral Anticoagulants Is Associated with Ischemic Stroke and Its Severity.

ABSTRACT:

Background and purpose

In acute stroke patients, plasma concentrations of direct oral anticoagulants (DOAC) at hospital admission only poorly mirror DOAC exposure or the coagulation status at the time of the event. Here, we evaluated whether DOAC exposure and DOAC plasma concentration at the time of transient ischemic attacks (TIA) and ischemic strokes correlate with their likelihood of occurrence.

Methods

Prospectively, consecutive DOAC patients with acute ischemic stroke or TIA were included. Admission DOAC plasma concentrations were measured by ultraperformance liquid chromatography- tandem mass spectrometry. Individual DOAC exposure (area under the curve) and DOAC concentrations at event onset were derived from population pharmacokinetic analyses.

Results

DOAC exp

SUBMITTER: Rizos T 

PROVIDER: S-EPMC8829480 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature