Cytotoxin-Associated Gene A-Negative Helicobacter pylori Promotes Gastric Mucosal CX3CR1⁺CD4⁺ Effector Memory T Cell Recruitment in Mice.

ABSTRACT:

Background

Helicobacter pylori can cause many kinds of gastric disorders, ranging from gastritis to gastric cancer. Cytotoxin-associated gene A (CagA)⁺ H. pylori is more likely to cause gastric histopathologic damage than CagA^- H. pylori. However, the underlying mechanism needs to be further investigated.

Materials and methods

Mice were intragastrically administered equal amounts of CagA⁺ or CagA^- H. pylori. Four weeks later, 24 chemokines in stomachs were measured using a mouse chemokine array, and the phenotypes of the recruited gastric CD4⁺ T cells were analyzed. The migration pathway was evaluated. Finally, the correlation between each pair among the recruited CD4⁺ T cell sub-po

SUBMITTER: Sun H 

PROVIDER: S-EPMC8829513 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature