Gene expression analysis reveals immune and metabolic candidate pathways in the pathogenesis of chronic otitis media.

ABSTRACT:

Objectives

Chronic otitis media (COM) is a common disease and causes significant hearing impairment in many adults. Our study aimed to investigate the immune response in COM adult patients through RNA sequencing.

Methods

In this study, we enrolled four adult COM patients and five healthy controls (HCs) to analyze and compare the mRNA signatures in their peripheral blood mononuclear cells (PBMCs). Gene Ontology functional enrichment and Kyoto Encyclopedia of Genes and Genomes pathway analyses were performed on the differentially expressed genes between the COM patients and the HCs. Furthermore, the immune cell proportions of the two groups were estimated by CIBERSORT. The GSE125532, GSE27990, and GSE23140 gene expression profiles were also retrieved and analyzed for compariso

SUBMITTER: Lin S 

PROVIDER: S-EPMC8829611 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature