Association of Titin Variations With Late-Onset Dilated Cardiomyopathy.

ABSTRACT:

Importance

Dilated cardiomyopathy (DCM) is frequently caused by genetic factors. Studies identifying deleterious rare variants have predominantly focused on early-onset cases, and little is known about the genetic underpinnings of the growing numbers of patients with DCM who are diagnosed when they are older than 60 years (ie, late-onset DCM).

Objective

To investigate the prevalence, type, and prognostic impact of disease-associated rare variants in patients with late-onset DCM.

Design, setting, and participants

A population of patients with late-onset DCM who had undergone genetic testing in 7 international tertiary referral centers worldwide were enrolled from March 1990 to August 2020. A positive genotype was defined as the presence of pathogenic or likely pathogen

SUBMITTER: Cannata A 

PROVIDER: S-EPMC8829739 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature