Association of Spironolactone Use With Risk of Cancer: A Systematic Review and Meta-analysis.

ABSTRACT:

Importance

While originally approved for the management of heart failure, hypertension, and edema, spironolactone is commonly used off label in the management of acne, hidradenitis, androgenetic alopecia, and hirsutism. However, spironolactone carries an official warning from the US Food and Drug Administration regarding potential for tumorigenicity.

Objective

To determine the pooled occurrence of cancers, in particular breast and prostate cancers, among those who were ever treated with spironolactone.

Data sources

PubMed, Cochrane Library, Embase, and Web of Science were searched from inception through June 11, 2021. The search was restricted to studies in the English language.

Study selection

Included studies reported the occurrence of cancers in men and wome

SUBMITTER: Bommareddy K 

PROVIDER: S-EPMC8829743 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature