T cell immune awakening in response to immunotherapy is age-dependent.

ABSTRACT:

Background

Precision immuno-oncology approaches are needed to improve cancer care. We recently demonstrated that in patients with metastatic melanoma, an increase of clonality or diversity of the T cell receptor (TCR) repertoire of peripheral T cells following one cycle of immunotherapy is coincident with response to immune-checkpoint blockade (ICB). We also identified a subset of peripheral CD8⁺ immune-effector memory T cells (T_IE cells) whose expansion was associated with response to ICB and increased overall survival. To improve our understanding of peripheral T cell dynamics, we examined the clinical correlates associated with these immune signatures.

Methods

Fifty patients with metastatic melanoma treated with first-line anti-PD-1 ICB were included

SUBMITTER: Salih Z 

PROVIDER: S-EPMC8829752 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature