A feasibility randomised controlled trial of targeted oxygen therapy in mechanically ventilated critically ill patients.

ABSTRACT:

Background

Despite oxygen being the commonest drug administered to critically ill patients we do not know which oxygen saturation (SpO₂) target results in optimal survival outcomes in those receiving mechanical ventilation. We therefore conducted a feasibility randomised controlled trial in the United Kingdom (UK) to assess whether it would be possible to host a larger national multi-centre trial to evaluate oxygenation targets in mechanically ventilated patients.

Methods

We set out to recruit 60 participants across two sites into a trial in which they were randomised to receive conservative oxygenation (SpO₂ 88-92%) or usual care (control - SpO₂ ≥96%). The primary outcome was feasibility; factors related to safety and clinical outcomes were

SUBMITTER: Martin DS 

PROVIDER: S-EPMC8829765 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature