Dataset Information

Human serum albumin variants in China: a molecular epidemiological investigation and literature review.

ABSTRACT:

Background

Bisalbuminemia is a hereditary and/or acquired abnormality characterized by a double albumin (ALB) band on serum protein electrophoresis. However, there have been no epidemiological investigations of ALB variants in Chinese populations.

Methods

This retrospective study examined 71,963 unrelated subjects from five provinces in southern China. ALB variants were screened by cellulose acetate electrophoresis at pH 8.6 and ALB mutations were confirmed by polymerase chain reaction-DNA sequencing.

Results

The average incidence of inherited bisalbuminemia in the southern Chinese population was 0.0264% (19/71,963). Thirteen cases showed slow and six showed fast genetic variants on cellulose acetate electrophoresis. Four kinds of ALB variants were identified: proalbumin Lille (p.Arg23His), ALB Castel di Sangro (p.Lys560Glu), ALB Fukuoka-1 (p.Asp587Asn), and a novel ALB Wuxi (p.Lys562Glu). The gene frequency of ALB variants in the Wuxi region (0.126%, 13/10,297) was significantly higher than in other regions in southern China, and 90.9% (10/11) of cases of proalbumin Lille were also found in the Wuxi region.

Conclusions

This study provides the first report of the detailed prevalence and molecular characterization of ALB variants in southern China. Compared with other areas of China, Wuxi had a different pattern of ALB variants and a high prevalence of proalbumin Lille.

SUBMITTER: Wu JR

PROVIDER: S-EPMC8829792 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Publications

Human serum albumin variants in China: a molecular epidemiological investigation and literature review.

Wu Jiao-Ren JR Lin Min M Lin Fen F Zhan Xiao-Fen XF Wang Jun-Li JL Yang Hui H Luo Zhao-Yun ZY Ma Zhan-Zhong ZZ Wang Chun-Fang CF Yang Li-Ye LY

The Journal of international medical research 20211201 12

<h4>Background</h4>Bisalbuminemia is a hereditary and/or acquired abnormality characterized by a double albumin (ALB) band on serum protein electrophoresis. However, there have been no epidemiological investigations of ALB variants in Chinese populations.<h4>Methods</h4>This retrospective study examined 71,963 unrelated subjects from five provinces in southern China. ALB variants were screened by cellulose acetate electrophoresis at pH 8.6 and <i>ALB</i> mutations were confirmed by polymerase ch ...[more]

PMID: 34919010

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Dataset Information

Human serum albumin variants in China: a molecular epidemiological investigation and literature review.

Background

Methods

Results

Conclusions

Publications

Human serum albumin variants in China: a molecular epidemiological investigation and literature review.

Similar Datasets

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