Ontology highlight
ABSTRACT:
SUBMITTER: Koteva K
PROVIDER: S-EPMC8829947 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Koteva Kalinka K Sychantha David D Rotondo Caitlyn M CM Hobson Christian C Britten James F JF Wright Gerard D GD
ACS omega 20220126 5
The aminopolycarboxylic acid aspergillomarasmine A (AMA) is a natural Zn<sup>2+</sup> metallophore and inhibitor of metallo-β-lactamases (MBLs) which reverses β-lactam resistance. The first crystal structure of an AMA coordination complex is reported and reveals a pentadentate ligand with distorted octahedral geometry. We report the solid-phase synthesis of 23 novel analogs of AMA involving structural diversification of each subunit (l-Asp, l-APA1, and l-APA2). Inhibitory activity was evaluated ...[more]