Association of peripheral immunity with cognition, neuroimaging, and Alzheimer's pathology.

ABSTRACT:

Background

Neuroinflammation has been considered to be a driving force of Alzheimer's disease. However, the association between peripheral immunity and AD has been rarely investigated.

Methods

Separate regression analyses were conducted to explore the associations among peripheral immune markers and cognition, neuroimaging, and AD pathology. Causal mediation analyses were used to investigate whether the associations with cognition were mediated by AD pathology.

Results

A total of 1107 participants (43.9% female, mean age of 73.2 years) from the Alzheimer's Disease Neuroimaging Initiative (ADNI) were included. Regression analyses indicated that elevated neutrophils (NEU) count and neutrophil-lymphocyte ratio (NLR) were associated with lower levels of global cognition,

SUBMITTER: Hou JH 

PROVIDER: S-EPMC8830026 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature