Central nervous system macrophages in progressive multiple sclerosis: relationship to neurodegeneration and therapeutics.

ABSTRACT: There are over 15 disease-modifying drugs that have been approved over the last 20 years for the treatment of relapsing-remitting multiple sclerosis (MS), but there are limited treatment options available for progressive MS. The development of new drugs for the treatment of progressive MS remains challenging as the pathophysiology of progressive MS is poorly understood.The progressive phase of MS is dominated by neurodegeneration and a heightened innate immune response with trapped immune cells behind a closed blood-brain barrier in the central nervous system. Here we review microglia and border-associated macrophages, which include perivascular, meningeal, and choroid plexus macrophages, during the progressive phase of MS. These cells are vital and are largely the basis to define lesion t

SUBMITTER: Kamma E 

PROVIDER: S-EPMC8830034 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature