Metallo-β-Lactamase Inhibitor Phosphonamidate Monoesters.

ABSTRACT: Being the second leading cause of death and the leading cause of disability-adjusted life years worldwide, infectious diseases remain-contrary to earlier predictions-a major consideration for the public health of the 21^st century. Resistance development of microbes to antimicrobial drugs constitutes a large part of this devastating problem. The most widely spread mechanism of bacterial resistance operates through the degradation of existing β-lactam antibiotics. Inhibition of metallo-β-lactamases is expected to allow the continued use of existing antibiotics, whose applicability is becoming ever more limited. Herein, we describe the synthesis, the metallo-β-lactamase inhibition activity, the cytotoxicity studies, and the NMR spectroscopic determination of the protein binding sit

SUBMITTER: Palica K 

PROVIDER: S-EPMC8830069 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature