Bex1 is essential for ciliogenesis and harbours biomolecular condensate-forming capacity.

ABSTRACT:

Background

Primary cilia are sensory organelles crucial for organ development. The pivotal structure of the primary cilia is a microtubule that is generated via tubulin polymerization reaction that occurs in the basal body. It remains to be elucidated how molecules with distinct physicochemical properties contribute to the formation of the primary cilia.

Results

Here we show that brain expressed X-linked 1 (Bex1) plays an essential role in tubulin polymerization and primary cilia formation. The Bex1 protein shows the physicochemical property of being an intrinsically disordered protein (IDP). Bex1 shows cell density-dependent accumulation as a condensate either in nucleoli at a low cell density or at the apical cell surface at a high cell density. The apical Bex1 localizes t

SUBMITTER: Hibino E 

PROVIDER: S-EPMC8830175 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature