Anti-Toxoplasma gondii effect of lupane-type triterpenes from the bark of black alder (Alnus glutinosa) and identification of a potential target by reverse docking.

ABSTRACT: Toxoplasmosis is a worldwide parasitosis that is generally benign. The infestation may pose a risk to immunocompromized patients and to fetuses when pregnant women have recently seroconverted. Current treatments have numerous side effects and chemoresistance is emerging, hence the need to find new anti-Toxoplasma gondii substances. This study focuses on the antiparasitic potential of lupane-type pentacyclic triterpenes isolated from the bark of black alder (Alnus glutinosa), as well as the hypothesis of their macromolecular target by an original method of reverse docking. Among the isolated triterpenes, betulone was the most active compound with an IC₅₀ of 2.7 ± 1.2 μM, a CC₅₀ greater than 80 μM, and a selectivity index of over 29.6. An additional study of the anti-T.

SUBMITTER: Darme P 

PROVIDER: S-EPMC8830292 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature