Maternal Complications and Prescription Opioid Exposure During Pregnancy: Using Marginal Structural Models.

ABSTRACT:

Introduction

Prescription opioids are frequently used for pain management in pregnancy. Studies examining perinatal complications in mothers who received prescription opioids during pregnancy are still limited.

Objectives

The aim of this study was to assess the association of prescription opioid use and maternal pregnancy and obstetric complications.

Methods

This retrospective cohort study with the Rhode Island (RI) Medicaid claims data linked to vital statistics throughout 2008-2015 included pregnant women aged 12-55 years with one or multiple live births. Women were excluded if they had cancer, opioid use disorder, or opioid dispensing prior to but not during pregnancy. Main outcomes included adverse pregnancy and obstetric complications. Marginal Structural Cox Mod

SUBMITTER: Wen X 

PROVIDER: S-EPMC8830421 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature