Cu-Catalyzed Site-Selective Benzylic Chlorination Enabling Net C-H Coupling with Oxidatively Sensitive Nucleophiles.

ABSTRACT: Site-selective chlorination of benzylic C-H bonds is achieved using a Cu^ICl/bis(oxazoline) catalyst with N-fluorobenzenesulfonimide as the oxidant and KCl as a chloride source. This method exhibits higher benzylic selectivity, relative to established chlorination protocols, and is compatible with diverse alkyl arenes. Sequential benzylic C-H chlorination/nucleophilic substitution affords C-O, C-S, and C-N coupling products with oxidatively sensitive coupling partners.

SUBMITTER: Lopez MA 

PROVIDER: S-EPMC8830506 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature