Microbial Characteristics and Genomic Analysis of an ST11 Carbapenem-Resistant Klebsiella pneumoniae Strain Carrying bla _KPC-2 Conjugative Drug-Resistant Plasmid.

ABSTRACT:

Background

The sequence type 11 (ST11) carbapenem-resistant Klebsiella pneumoniae (CRKP) carrying bla _KPC-2 has been widespread all over the world, and it has been reported frequently in China. The bla _KPC-2 located on the mobile genetic element brings tremendous pressure to control the spread and outbreak of resistant bacteria. Whole-genome sequencing (WGS) technology can comprehensively and in-depth display the molecular characteristics of drug-resistant bacteria, providing a basis for evaluating the genetic diversity within the CRKP genome.

Methods

The ST11 CRKP in this study was collected in the intensive care unit of a major teaching hospital. PCR and Sanger sequencing confirmed the existence of bla

SUBMITTER: Zeng L 

PROVIDER: S-EPMC8830775 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature