The Protective Role of IL-36/IL-36R Signal in Con A-Induced Acute Hepatitis.

ABSTRACT: The IL-36 family, including IL-36α, IL-36β, IL-36γ, and IL-36R antagonist, belong to the IL-1 superfamily. It was reported that IL-36 plays a role in immune diseases. However, it remains unclear how IL-36 regulates inflammation. To determine the role of IL-36/IL-36R signaling pathways, we established an acute hepatitis mouse model (C57BL/6) by i.v. injection of the plant lectin Con A. We found that the levels of IL-36 were increased in the liver after Con A injection. Our results demonstrated the infiltrated neutrophils, but not the hepatocytes, were the main source of IL-36 in the liver. Using the IL-36R^-/- mouse model (H-2^b), we surprisingly found that the absence of IL-36 signals led to aggravated liver injury, as evidenced by increased mortality, elevated serum al

SUBMITTER: Wang X 

PROVIDER: S-EPMC8830780 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature