RNA-Binding Protein IGF2BP1 Associated With Prognosis and Immunotherapy Response in Lung Adenocarcinoma.

ABSTRACT: N6-methyladenosine (m⁶A) is the most common modification in eukaryotic RNAs and plays a vital role in the tumorigenesis and metastasis of various cancers. However, a comprehensive study of m⁶A methylation regulators in lung adenocarcinoma (LUAD) is still lacking. The present study aimed to systematically explore the role of m⁶A methylation regulators in LUAD. RNA sequencing data of 20 m⁶A methylation regulators and clinical data of LUAD patients were downloaded from The Cancer Genome Atlas (TCGA) database. The prognosis value of m⁶A methylation regulators in LUAD was evaluated using the Gene Expression Profiling Interactive Analysis (GEPIA) and PrognoScan database. The correlation between IGF2BP1 and immune infiltrates in LUAD w

SUBMITTER: Liu J 

PROVIDER: S-EPMC8830935 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature