NAD⁺ in COVID-19 and viral infections.

ABSTRACT: NAD⁺, as an emerging regulator of immune responses during viral infections, may be a promising therapeutic target for coronavirus disease 2019 (COVID-19). In this Opinion, we suggest that interventions that boost NAD⁺ levels might promote antiviral defense and suppress uncontrolled inflammation. We discuss the association between low NAD⁺ concentrations and risk factors for poor COVID-19 outcomes, including aging and common comorbidities. Mechanistically, we outline how viral infections can further deplete NAD⁺ and its roles in antiviral defense and inflammation. We also describe how coronaviruses can subvert NAD⁺-mediated actions via genes that remove NAD⁺ modifications and activate the NOD-, LRR-, and pyrin domain-containi

SUBMITTER: Zheng M 

PROVIDER: S-EPMC8831132 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature