Distinct prognostic value of different portal hypertension-associated features in patients with primary biliary cholangitis.

ABSTRACT:

Background

Primary biliary cholangitis (PBC) may progress to cirrhosis and clinically significant portal hypertension (CSPH). This study assesses different features of CSPH and their distinct prognostic impact regarding decompensation and survival in patients with PBC.

Methods

Patients with PBC were identified during a database query of our digital patient reporting system.

Results

A total of 333 PBC patients (mean age 54.3 years, 86.8% females, median follow-up 5.8 years) were retrospectively assessed and 127 (38.1%) showed features of CSPH: 63 (18.9%) developed varices, 98 (29.4%) splenomegaly, 62 (18.6%) ascites and 20 (15.7%) experienced acute variceal bleeding. Splenomegaly, portosystemic collaterals and esophageal varices were associated with an increased 5-year

SUBMITTER: Burghart L 

PROVIDER: S-EPMC8831368 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature