MYC Levels Regulate Metastatic Heterogeneity in Pancreatic Adenocarcinoma.

ABSTRACT: The degree of metastatic disease varies widely among patients with cancer and affects clinical outcomes. However, the biological and functional differences that drive the extent of metastasis are poorly understood. We analyzed primary tumors and paired metastases using a multifluorescent lineage-labeled mouse model of pancreatic ductal adenocarcinoma (PDAC)-a tumor type in which most patients present with metastases. Genomic and transcriptomic analysis revealed an association between metastatic burden and gene amplification or transcriptional upregulation of MYC and its downstream targets. Functional experiments showed that MYC promotes metastasis by recruiting tumor-associated macrophages, leading to greater bloodstream intravasation. Consistent with these findings, metastatic prog

SUBMITTER: Maddipati R 

PROVIDER: S-EPMC8831468 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature