Neutrophil-to-lymphocyte ratio is a novel predictor of venous thrombosis in polycythemia vera.

ABSTRACT: We investigated the neutrophil-to-lymphocyte ratio (NLR) as a predictor of thrombosis in polycythemia vera (PV). After a median follow-up of 2.51 years, of 1508 PV patients enrolled in the ECLAP study, 82 and 84 developed arterial and venous thrombosis, respectively. Absolute counts of total leukocytes, neutrophils, lymphocytes, platelets, and the NLR were tested by generalized additive models (GAM) to evaluate their trend in continuous scale of thrombotic risk. Only for venous thrombosis, we showed that baseline absolute neutrophil and lymphocyte counts were on average respectively higher (median: 6.8 × 10⁹/L, p = 0.002) and lower (median: 1.4 × 10⁹/L, p = 0.001), leading to increased NLR values (median: 5.1, p = 0.002). In multivariate analysis, the risk of venous t

SUBMITTER: Carobbio A 

PROVIDER: S-EPMC8831521 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature