Demarcating the boundary conditions of memory reconsolidation: An unsuccessful replication.

ABSTRACT: Disrupting memory reconsolidation provides an opportunity to abruptly reduce the behavioural expression of fear memories with long-lasting effects. The success of a reconsolidation intervention is, however, not guaranteed as it strongly depends on the destabilization of the memory. Identifying the necessary conditions to trigger destabilization remains one of the critical challenges in the field. We aimed to replicate a study from our lab, showing that the occurrence of a prediction error (PE) during reactivation is necessary but not sufficient for destabilization. We tested the effectiveness of a reactivation procedure consisting of a single PE, compared to two control groups receiving no or multiple PEs. All participants received propranolol immediately after reactivation and were tested

SUBMITTER: Stemerding LE 

PROVIDER: S-EPMC8831535 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature