IκB-ζ signaling promotes chondrocyte inflammatory phenotype, senescence, and erosive joint pathology.

ABSTRACT: Osteoarthritis is a joint disease characterized by a poorly-defined inflammatory response that does not encompass a massive immune cell infiltration yet contributes to cartilage degradation and loss of joint mobility, suggesting a chondrocyte intrinsic inflammatory response. Using primary chondrocytes from joints of osteoarthritic mice and patients, we first show that these cells express ample pro-inflammatory markers and RANKL in an NF-κB dependent manner. The inflammatory phenotype of chondrocytes was recapitulated by exposure of chondrocytes to IL-1β and bone particles, which were used to model bone matrix breakdown products revealed to be present in synovial fluid of OA patients, albeit their role was not defined. We further show that bone particles and IL-1β can promote senescent and

SUBMITTER: Arra M 

PROVIDER: S-EPMC8831569 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature