High-speed rail model reveals the gene tandem amplification mediated by short repeated sequence in eukaryote.

ABSTRACT: The occurrence of gene duplication/amplification (GDA) provide potential material for adaptive evolution with environmental stress. Several molecular models have been proposed to explain GDA, recombination via short stretches of sequence similarity plays a crucial role. By screening genomes for such events, we propose a "SRS (short repeated sequence) *N + unit + SRS*N" amplified unit under USCE (unequal sister-chromatid exchange) for tandem amplification mediated by SRS with different repeat numbers in eukaryotes. The amplified units identified from 2131 well-organized amplification events that generate multi gene/element copy amplified with subsequent adaptive evolution in the respective species. Genomic data we analyzed showed dynamic changes among related species or subspecies or plants

SUBMITTER: Chen H 

PROVIDER: S-EPMC8831618 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature