Liu Shen Capsule Alters Airway Microbiota Composition and Metabolite Profiles in Healthy Humans.

ABSTRACT: Alteration in airway microbiota composition and perturbations in microbe-metabolites interactions have been proposed as markers of many diseases. Liu Shen (LS) capsule, a traditional Chinese medicine, was proved as favorable in treating respiratory diseases. However, the effects of the LS capsule in terms of regulating human microorganisms and metabolite profiles are not well known. This study aimed to define and compare the respiratory microbiota composition and circulating and fecal metabolite profiles before and after LS capsule administration. A total of 30 healthy volunteers were recruited. The pharyngeal swab samples were collected for 16S rRNA gene sequencing. The serum and fecal samples were collected to analyze the non-targeted ultra-performance liquid chromatography-tandem mass s

SUBMITTER: Wang X 

PROVIDER: S-EPMC8831732 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature