Anti-HCV Tannins From Plants Traditionally Used in West Africa and Extracted With Green Solvents.

ABSTRACT: Millions of people are still infected with hepatitis C virus (HCV) nowadays. Although recent antivirals targeting HCV proteins are very efficient, they are not affordable for many people infected with this virus. Therefore, new and more accessible treatments are needed. Several Ivorian medicinal plants are traditionally used to treat "yellow malaria", a nosological category including illness characterized by symptomatic jaundice such as hepatitis. Therefore, some of these plants might be active against HCV. An ethnobotanical survey in Côte d'Ivoire allowed us to select such medicinal plants. Those were first extracted with methanol and tested for their anti-HCV activity. The most active ones were further studied to specify their IC₅₀ and to evaluate their toxicity in vitro

SUBMITTER: Bamba M 

PROVIDER: S-EPMC8831738 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature