Assessment of causal direction between thyroid function and cardiometabolic health: a Mendelian randomization study.

ABSTRACT:

Background

Growing evidence have demonstrated that thyroid hormones have been involved in the processes of cardiovascular metabolism. However, the causal relationship of thyroid function and cardiometabolic health remains partly unknown.

Methods

The Mendelian randomization (MR) was used to test genetic, potentially causal relationships between instrumental variables and cardiometabolic traits. Genetic variants of free thyroxine (FT4) and thyrotropin (TSH) levels within the reference range were used as instrumental variables. Data for genetic associations with cardiometabolic diseases were acquired from the genome-wide association studies of the FinnGen, CARDIoGRAM and CARDIoGRAMplusC4D, CHARGE, and MEGASTROKE. This study was conducted using summary statistic data from large,

SUBMITTER: Wang JJ 

PROVIDER: S-EPMC8832047 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature