Understanding pancreatic cancer stem cells and their role in carcinogenesis: a narrative review.

ABSTRACT:

Objective

The purpose of this review article is to describe the pathogenesis of pancreatic cancer and to better understand the role of abnormal stem cells in the development of pancreatic cancer.

Background

Pancreatic cancer is a highly fatal disease that is caused by the uncontrolled proliferation of pancreatic exocrine or neuroendocrine glands. It is believed that pancreatic cancers arise from a small population of abnormal cancer stem cells (CSCs) that promote tumorigenesis, tumor metastasis and therapeutic resistance. The molecular markers CD133, CXCR4, DCLK1, c-MET, ABCG2 and Lgr5 are routinely used to detected and observe the behaviours of pancreatic cancer stem cells (PCSCs).

Methods

A comprehensive search was performed on PubMed, Google Scholar, Scopus, Clinic

SUBMITTER: Sumbly V 

PROVIDER: S-EPMC8832159 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature