Associations Between Retinal Nerve Fiber Layer and Ganglion Cell Layer in Middle Age and Cognition From Childhood to Adulthood.

ABSTRACT:

Importance

The retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) have been proposed as potential biomarkers for Alzheimer disease (AD). Although a number of studies have shown that knowing the thickness of RNFL and GCL can help differentiate between patients with AD and healthy controls, it is unclear whether these associations are observable earlier in life.

Objective

To examine whether RNFL and GCL thickness was associated with global cognitive performance in middle age and in childhood and with a decline in cognitive performance from childhood to adulthood and whether RNFL and GCL thickness was associated with decline in specific cognitive domains over the same period.

Design, setting, and participants

This longitudinal cohort study involved members of

SUBMITTER: Barrett-Young A 

PROVIDER: S-EPMC8832305 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature