Prediction of early clinical response in patients receiving tofacitinib in the OCTAVE Induction 1 and 2 studies.

ABSTRACT:

Introduction

Tofacitinib is an oral, small molecule Janus kinase inhibitor for the treatment of ulcerative colitis (UC). Outcome prediction based on early treatment response, along with clinical and laboratory variables, would be very useful for clinical practice. The aim of this study was to determine early variables predictive of responder status in patients with UC treated with tofacitinib.

Methods

Data were collected from patients treated with tofacitinib 10 mg twice daily in the OCTAVE Induction 1 and 2 studies (NCT01465763 and NCT01458951). Logistic regression and random forest analyses were performed to determine the power of clinical and/or laboratory variables to predict 2- and 3-point partial Mayo score responder status of patients at Weeks 4 or 8 after baseline.

SUBMITTER: Lees CW 

PROVIDER: S-EPMC8832332 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature