The organization and development of cortical interneuron presynaptic circuits are area specific.

ABSTRACT: Parvalbumin and somatostatin inhibitory interneurons gate information flow in discrete cortical areas that compute sensory and cognitive functions. Despite the considerable differences between areas, individual interneuron subtypes are genetically invariant and are thought to form canonical circuits regardless of which area they are embedded in. Here, we investigate whether this is achieved through selective and systematic variations in their afferent connectivity during development. To this end, we examined the development of their inputs within distinct cortical areas. We find that interneuron afferents show little evidence of being globally stereotyped. Rather, each subtype displays characteristic regional connectivity and distinct developmental dynamics by which this connectivity is ac

SUBMITTER: Pouchelon G 

PROVIDER: S-EPMC8832360 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature