Bacterial and viral coinfection in idiopathic pulmonary fibrosis patients: the prevalence and possible role in disease progression.

ABSTRACT:

Background

Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial pneumonia of unknown aetiology with a mean survival rate of less than 3 years. No previous studies have been performed on the role of co-infection (viral and bacterial infection) in the pathogenesis and progression of IPF. In this study, we investigated the role of viral/bacterial infection and coinfection and their possible association with pathogenesis and progression of IPF.

Methods

We investigated the prevalence and impact of bacterial and viral coinfection in IPF patients (n = 67) in the context of pulmonary function (FVC, FEV₁ and DL_CO), disease status and mortality risk. Using principal component analysis (PCA), we also investigated the relationship between distribution

SUBMITTER: Moghoofei M 

PROVIDER: S-EPMC8832419 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature